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An update on the biochemistry of 5-fluorouracil.

作者信息

Ardalan B, Glazer R

出版信息

Cancer Treat Rev. 1981 Sep;8(3):157-67. doi: 10.1016/s0305-7372(81)80014-x.

DOI:10.1016/s0305-7372(81)80014-x
PMID:6272993
Abstract
摘要

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1
An update on the biochemistry of 5-fluorouracil.
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2
[Activities of enzymes converting 5-fluorouracil to 5-fluorouridine-5' monophosphate and 5-fluorodeoxyuridine-5' monophosphate in subcultured cell lines and solid tumor tissues].[传代细胞系和实体瘤组织中5-氟尿嘧啶转化为5-氟尿苷-5'-单磷酸和5-氟脱氧尿苷-5'-单磷酸的酶活性]
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Biochemical basis for the differential sensitivity of human T- and B-lymphocyte lines to 5-fluorouracil.人类T淋巴细胞系和B淋巴细胞系对5-氟尿嘧啶敏感性差异的生化基础
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6
Biochemical characteristics of a 5-fluorouracil-resistant subline of P388 leukemia.P388白血病5-氟尿嘧啶耐药亚系的生化特性
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Comparison of pyrimidine nucleotide synthetic enzymes involved in 5-fluorouracil metabolism between human adenocarcinomas and squamous cell carcinomas.人腺癌与鳞状细胞癌中参与5-氟尿嘧啶代谢的嘧啶核苷酸合成酶的比较。
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Sensitivity of human, murine, and rat cells to 5-fluorouracil and 5'-deoxy-5-fluorouridine in relation to drug-metabolizing enzymes.人、小鼠和大鼠细胞对5-氟尿嘧啶和5'-脱氧-5-氟尿苷的敏感性与药物代谢酶的关系。
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Comparative study of the effects of PEGylated interferon-α2a versus 5-fluorouracil on cancer stem cells in a rat model of hepatocellular carcinoma.聚乙二醇化干扰素-α2a与5-氟尿嘧啶对大鼠肝细胞癌模型中癌症干细胞影响的比较研究
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In vivo effects of immunomodulators in a murine model of Fluorouracil-induced mucositis.免疫调节剂在氟尿嘧啶诱导的小鼠黏膜炎模型中的体内效应。
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The Leishmania donovani UMP synthase is essential for promastigote viability and has an unusual tetrameric structure that exhibits substrate-controlled oligomerization.
杜氏利什曼原虫 UMP 合酶对于前鞭毛体的存活是必需的，并且具有不寻常的四聚体结构，表现出底物控制的寡聚化。
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4
Does leucovorin alter the intratumoral pharmacokinetics of 5-fluorouracil (5-FU)? A Southwest Oncology Group study.亚叶酸是否会改变5-氟尿嘧啶（5-FU）的肿瘤内药代动力学？一项西南肿瘤协作组的研究。
Invest New Drugs. 2002 Nov;20(4):369-76. doi: 10.1023/a:1020651311866.
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5-fluorouracil metabolism monitored in vivo by 19F NMR.通过19F核磁共振在体内监测5-氟尿嘧啶代谢。
Br J Cancer. 1984 Jul;50(1):113-7. doi: 10.1038/bjc.1984.146.
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Clinical pharmacokinetics of commonly used anticancer drugs.常用抗癌药物的临床药代动力学
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Thymidine as an anticancer agent, alone or in combination. A biochemical appraisal.胸苷作为一种抗癌剂，单独使用或联合使用。一项生化评估。
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Antitumor activity of BOF-A2, a new 5-fluorouracil derivative.新型5-氟尿嘧啶衍生物BOF-A2的抗肿瘤活性
Jpn J Cancer Res. 1989 Feb;80(2):173-81. doi: 10.1111/j.1349-7006.1989.tb02286.x.
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Effect of 5-fluorouracil combination therapy on RNA processing in human colonic carcinoma cells.5-氟尿嘧啶联合疗法对人结肠癌细胞RNA加工的影响。
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Antineoplastic drugs in 1990. A review (Part II).1990年的抗肿瘤药物。综述（第二部分）。
Drugs. 1990 May;39(5):652-73. doi: 10.2165/00003495-199039050-00003.