Goffman T, Cantrell J, Schein P
Clin Chem. 1981 Dec;27(12):2068-9.
In this case of mixed small cell--large cell cancer of the lung in an elderly woman, creatine kinase (EC 2.7.3.2) isoenzymes were assayed serially because of chest pain. The proportions of serum CK-BB and CK-MB isoenzyme activities were persistently above normal (CK-MB 10-18%, normal less than 5%). Electrocardiograms revealed no signs of ischemia or infarction. At autopsy no gross or microscopic infarction or inflammation of the heart was seen. There was also no infarction of smooth or skeletal muscle. The tumor was the probable source of most of the circulating CK-MB isoenzyme. Future cases may pose a similar diagnostic dilemma: differentiating creatine kinase that is present as a result of myocardial infarction from tumor-related CK-MB. Whether or not CK-MB assay could be useful in detecting tumors remains to be investigated.
在这位老年女性的肺混合性小细胞-大细胞癌病例中，因胸痛对肌酸激酶（EC 2.7.3.2）同工酶进行了连续检测。血清CK-BB和CK-MB同工酶活性比例持续高于正常水平（CK-MB为10 - 18%，正常低于5%）。心电图未显示缺血或梗死迹象。尸检时，心脏未见大体或显微镜下的梗死或炎症。平滑肌或骨骼肌也无梗死。肿瘤可能是循环中大部分CK-MB同工酶的来源。未来的病例可能会带来类似的诊断难题：区分心肌梗死导致的肌酸激酶和肿瘤相关的CK-MB。CK-MB检测是否可用于检测肿瘤仍有待研究。
