Manorama H T, Shenoy D R
J Int Med Res. 1978;6(1):46-9. doi: 10.1177/030006057800600108.
Sixty cases of trichomonal vaginitis were randomly allocated to treatment with tinidazole or metronidazole, both administered as a 2 g single dose. One patient on tinidazole did not complete her follow-up. Parasitological cure was obtained in all patients in both the treatment groups. A satisfactory clinical response was obtained in all 29 patients on tinidazole, and in 27 out of 30 (90%) on metronidazole. Complete relief of sumptoms was obtained in 62% (18/29) and 13% (4/30) of patients ontinidazole and metronidazole, respectively (p less than 0.01). Ten patients on tinidazole and 24 on metronidazole manifested side-effects. The frequency and severity of side-effects were much more in the metronidazole group (p less than 0.01). Tinidazole has distinct advantages over metronidazole in the one-dose treatment of trichomonal vaginitis.
60例滴虫性阴道炎患者被随机分为两组，分别接受替硝唑或甲硝唑治疗，均采用2g单剂量给药。1例接受替硝唑治疗的患者未完成随访。两个治疗组的所有患者均获得了寄生虫学治愈。接受替硝唑治疗的29例患者和接受甲硝唑治疗的30例患者中的27例（90%）获得了满意的临床反应。接受替硝唑和甲硝唑治疗的患者中，症状完全缓解的分别为62%（18/29）和13%（4/30）（p<0.01）。10例接受替硝唑治疗的患者和24例接受甲硝唑治疗的患者出现了副作用。甲硝唑组副作用的频率和严重程度更高（p<0.01）。在滴虫性阴道炎的单剂量治疗中，替硝唑比甲硝唑具有明显优势。
