Gülmezoglu A M, Forna F
Special Department of Research, Development and Research Training in Human Reproduction, UNDP/UNFPA/WHO/World Bank, World Health Organisation, Geneva 27, Switzerland, CH-1211.
Cochrane Database Syst Rev. 2000;2003(2):CD000218. doi: 10.1002/14651858.CD000218.
Around 120 million women worldwide suffer from Trichomonas vaginalis vaginitis every year. The infection is sexually transmitted and is believed to facilitate HIV transmission. The objective of the review is to assess the effects of various treatment strategies for trichomoniasis in women.
We searched the Cochrane Controlled Trials Register, MEDLINE, and EMBASE. Trials were also identified from reference lists of reviews, through pharmaceutical companies, and by informal discovery. Only published data were used in this review. Date of the most recent search: May, 1999.
Randomized or quasi-randomized trials in women with trichomoniasis of different treatment strategies, different antitrichomonal drugs or doses were eligible.
Trial quality was assessed and data extracted by two reviewers independently using standard criteria.
Fifty-two trials were included. Nitroimidazoles seem to be effective in achieving parasitological cure in the short term follow-ups. Partner treatment can be effective in decreasing longer term re-infection rates.
REVIEWER'S CONCLUSIONS: Parasitological cure can be achieved by single oral dose of nitroimidazoles. Further research should focus on developing effective partner treatment strategies to prevent re-infections and reduce trichomoniasis prevalence.
全球每年约有1.2亿女性患有滴虫性阴道炎。该感染通过性传播，并且被认为会促进艾滋病病毒的传播。本综述的目的是评估针对女性滴虫病的各种治疗策略的效果。
我们检索了Cochrane对照试验注册库、MEDLINE和EMBASE。还通过综述的参考文献列表、制药公司以及非正式渠道查找试验。本综述仅使用已发表的数据。最近一次检索日期：1999年5月。
针对患有滴虫病的女性采用不同治疗策略、不同抗滴虫药物或剂量的随机或半随机试验符合要求。
由两名评价员独立使用标准标准评估试验质量并提取数据。
纳入了52项试验。在短期随访中，硝基咪唑类药物似乎能有效实现寄生虫学治愈。性伴侣治疗可有效降低长期再感染率。
单次口服硝基咪唑类药物可实现寄生虫学治愈。进一步的研究应侧重于制定有效的性伴侣治疗策略，以预防再感染并降低滴虫病的患病率。
