催乳素对人胎儿肾上腺体外分泌脱氢表雄酮（DHEA）、其硫酸盐（DHEA-S）和皮质醇的影响。

Effect of prolactin on the secretion of dehydroepiandrosterone (DHEA), its sulfate (DHEA-S), and cortisol by the human fetal adrenal in vitro.

作者信息

Taga M, Tanaka K, Liu T, Minaguchi H, Sakamoto S

出版信息

Endocrinol Jpn. 1981 Jun;28(3):321-7. doi: 10.1507/endocrj1954.28.321.

DOI:10.1507/endocrj1954.28.321

Abstract

The effect of prolactin on the secretions of dehydroepiandrosterone (DHEA) and its sulfate (DHEA-S) as well as that of cortisol were studied in vitro in order to investigate the possible regulatory role of prolactin on steroidogenesis of the human fetal adrenal at mid-gestational age. The addition of 0.5 microgram/ml of human prolactin to the incubation medium produced a significant (P less than 0.05) increase in DHEA, DHEA-S, and cortisol secretion. These results indicate that prolactin has a regulatory role in steroidogenesis in the human fetal adrenal at mid-gestation.

摘要

为了研究催乳素对孕中期人胎儿肾上腺类固醇生成的可能调节作用，在体外研究了催乳素对脱氢表雄酮（DHEA）及其硫酸盐（DHEA-S）以及皮质醇分泌的影响。向孵育培养基中添加0.5微克/毫升的人催乳素会使DHEA、DHEA-S和皮质醇分泌显著增加（P<0.05）。这些结果表明，催乳素在孕中期人胎儿肾上腺的类固醇生成中具有调节作用。