Vecchierini-Blineau M F, Thebaud H E, Dupouet L, Brochard D, Coville P, Feve J R, Guiheneuc P
Sem Hop. 1981;57(43-44):1823-30.
Twelve patients with chronic renal failure, on maintenance hemodialysis have a stereotyped illness. The dialysate was made up from a high level aluminium tap water. After having been on haemodialysis for 10 to 12 months, they suffer from more and more acute osteodystrophic, osteomalacic symptoms. Then, distinctive EEG abnormalities appear. These first symptoms allow an early diagnosis of the progressive dialytic encephalopathy. The neurological symptoms appear some months later. Eight patients died from this encephalopathy. Four patients are still alive and are, from at least two years, on maintenance haemodialysis with a free aluminium water. In these 4 cases, the evolution of the disease is good: osteomalacic symptoms disappear in a year; the neurological symptoms are still present though transient. EEG abnormalities remain and blood aluminium level is about 100 micrograms/L. These cases show, once more, the significant role of aluminium as an aetiological factor in "progressive dialysis encephalopathy".
12例维持性血液透析的慢性肾衰竭患者患有一种刻板的疾病。透析液由高铝自来水制成。在进行血液透析10至12个月后，他们出现越来越多的急性骨营养不良、骨软化症状。然后，出现明显的脑电图异常。这些最初症状可对进行性透析性脑病作出早期诊断。数月后出现神经症状。8例患者死于这种脑病。4例患者仍然存活，至少两年来一直使用无铝水进行维持性血液透析。在这4例病例中，疾病进展良好：骨软化症状在一年内消失；神经症状仍然存在但为一过性。脑电图异常仍然存在，血铝水平约为100微克/升。这些病例再次表明铝作为“进行性透析性脑病”病因学因素的重要作用。
