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[一名慢性血液透析患者的持续性可逆性脑病。铝盐可能的责任(作者译)]

[Prolonged and reversible encephalopathy in a chronic haemodialysis patient. Probable responsibility of aluminium salts (author's transl)].

作者信息

Buge A, Poisson M, Masson S, Bleibel J M, Lafforgue B, Raymond P, Jaudon M C

出版信息

Nouv Presse Med. 1978 Jun 10;7(23):2053-9.

PMID:673773
Abstract

A case of encephalopathy with elevation of plasma aluminium level in a patient treated by maintenance hemodialysis is reported. Clinical symptoms were made of moderate impairment of intellectual functions and of intermittent drowsiness. EEG after 3 minutes of hyperpnea evidenced bisynchronous anteriorly dominant intermittent delta waves. Plasma aluminium level, determined by atomic absorption spectrophotometry, was initially at 300 microgram/l (normal range greater than 40 microgram/l). After interruption of aluminium gels, clinical and EEG symptoms slowly subsided in 9 months, plasma aluminium level came down to 145 microgram/l. This picture of encephalopathy could preceede irreversible dialysis dementia in chronic dialysis patients.

摘要

报告了一例维持性血液透析患者出现血浆铝水平升高伴脑病的病例。临床症状包括智力功能中度受损和间歇性嗜睡。过度通气3分钟后的脑电图显示双同步的前头部优势间歇性δ波。通过原子吸收分光光度法测定的血浆铝水平最初为300微克/升(正常范围大于40微克/升)。停用铝凝胶后,临床和脑电图症状在9个月内逐渐缓解,血浆铝水平降至145微克/升。这种脑病情况可能先于慢性透析患者出现不可逆的透析性痴呆。

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