Zaĭdman A M, Rabinovich S S, Mokhova N M, Serpeninova N N
Zh Vopr Neirokhir Im N N Burdenko. 1981 Jul-Aug(4):18-23.
Three stages of cerebral metabolism differing in tension were revealed in the acute period of closed craniocerebral trauma. In the mobilization stage (1 hour after trauma) enzymatic reactions reflecting the activity of aerobic and anaerobic glycolysis are sharply intensified. In the resistance stage (from 3 hours to 2 weeks after trauma) stable conversion to anaerobic glycolysis is noted, which leads to marked deficiency in macroergic compounds. Activation of alpha-glycerophosphate, pentose shunt by means of pharmacological agents in combination with hypothermia may be recommended in this stage. In the restoration stage (more than 2 weeks after the trauma) the metabolic processes are gradually normalized and therapy need not be so intensive.
在闭合性颅脑创伤急性期，发现了三个紧张度不同的脑代谢阶段。在动员期（创伤后1小时），反映有氧和无氧糖酵解活性的酶促反应急剧增强。在抵抗期（创伤后3小时至2周），出现向无氧糖酵解的稳定转变，这导致高能化合物明显缺乏。在此阶段，可建议通过药物与低温相结合的方式激活α-磷酸甘油、戊糖旁路。在恢复期（创伤后2周以上），代谢过程逐渐恢复正常，治疗强度无需那么大。
