[Protein synthesis and oxidative activity of the brain in oxygen deficiency].

Biochemical and electron microscopic research methods showed disorders of the metabolism and the ultrastructure of the rat brain under the impact of experimental hypoxia and anoxia. Two to 3.5 hours after the exposure, the synthesis of protein in the neuronal fractions was impaired and the activity of the oxidative enzymes in the subfractions of synaptosomes and mitochondria was inhibited. The tissue ultrastructure was also impaired which was most pronounced in the synaptic processes of neurones. The data indicate fine morphochemical correlations at the subcellular level in the period immediately following post-hypoxic brain survival.