Novitskaia N A, Aksentsev S L, Lyskova T I, Okun' I M, Konev S V
Biokhimiia. 1981 Nov;46(11):1981-3.
Serotonin (10(-6)-10(-3) M) stimulates Na,K-ATPase in the rat brain cortex homogenate with a maximal effect at 10(-4) M. Deseril (10(-5) M), antagonist of serotonin receptors, removes the stimulating effect. Deseril has no influence on noradrenaline-induced ATPase activation; the alpha-adrenergic blocker phentolamine does not affect serotonin activation. The effects of the two transmitters are additive. It is assumed that the mediators interact with different membrane sites, serotonin activation being initiated via the serotonin receptors.
血清素（10⁻⁶ - 10⁻³M）可刺激大鼠脑皮质匀浆中的钠钾ATP酶，在10⁻⁴M时效果最佳。血清素受体拮抗剂地昔帕明（10⁻⁵M）可消除这种刺激作用。地昔帕明对去甲肾上腺素诱导的ATP酶激活没有影响；α-肾上腺素能阻滞剂酚妥拉明不影响血清素的激活作用。这两种递质的作用是相加的。假定这两种介质与不同的膜位点相互作用，血清素的激活是通过血清素受体启动的。
