Allikmets L Kh, Nurk A M
Biull Eksp Biol Med. 1981 Nov;92(11):571-2.
The morphine withdrawal syndrome was studied in male Wistar rats. Spontaneous aggressiveness, enhanced apomorphine aggressiveness, lowered pain threshold and decreased dopamine turnover were observed after withdrawal of 10-day treatment with the increasing doses of morphine (30-300 mg/kg). These changes attested to the increased sensitivity of dopamine receptors. Administration of morphine in conjunction with lithium chloride in a dose of 2 mekv/kg prevented the development of dopamine receptor hypersensitivity. Also, this method did not produce the increased spontaneous and apomorphine aggressiveness or the decreased dopamine turnover. Meanwhile the pain threshold remained lowered.
在雄性Wistar大鼠中研究了吗啡戒断综合征。在给予递增剂量吗啡（30 - 300毫克/千克）进行10天治疗后停药，观察到自发攻击性增强、阿扑吗啡诱导的攻击性增强、痛阈降低和多巴胺周转率降低。这些变化证明多巴胺受体敏感性增加。以2毫当量/千克的剂量将吗啡与氯化锂联合给药可防止多巴胺受体超敏反应的发生。此外，这种方法不会导致自发和阿扑吗啡诱导的攻击性增加或多巴胺周转率降低。同时，痛阈仍然降低。
