MacGregor G A, Fenton S, Alaghband-Zadeh J, Markandu N, Roulston J E, de Wardener H E
Br Med J (Clin Res Ed). 1981 Nov 21;283(6303):1355-7. doi: 10.1136/bmj.283.6303.1355.
A cytochemical technique that measures the ability of plasma to stimulate guinea-pig renal glucose-6-phosphate dehydrogenase (G6PD) activity in vitro, which is a marker of its ability to inhibit Na+-K+-adenosine-triphosphatase (Na+-K+-ATPase), was used in 19 patients with essential hypertension and 23 normotensive, healthy subjects. The ability of plasma to stimulate G6PD was significantly greater in the hypertensive patients when they were taking their normal sodium diet than in the normotensive subjects, and was significantly correlated with blood pressure. The ability of plasma to stimulate G6PD was inversely correlated with plasma renin activity in the hypertensive patients and increased with age and sodium intake in the normotensive subjects. These results support the hypothesis that essential hypertension, and also perhaps the increase in blood pressure with age in communities that consume large quantities of salt, is in part due to an increase in a circulating concentration of an inhibitor of Na+-N+-ATPase.
一种细胞化学技术用于检测19例原发性高血压患者和23例血压正常的健康受试者，该技术可测定血浆在体外刺激豚鼠肾葡萄糖-6-磷酸脱氢酶（G6PD）活性的能力，而G6PD活性是血浆抑制钠钾腺苷三磷酸酶（Na⁺-K⁺-ATP酶）能力的一个指标。高血压患者在正常钠饮食时，血浆刺激G6PD的能力显著高于血压正常者，且与血压显著相关。高血压患者血浆刺激G6PD的能力与血浆肾素活性呈负相关，而在血压正常者中则随年龄和钠摄入量增加。这些结果支持这样的假说，即原发性高血压以及大量摄入盐的社区中随年龄增长出现的血压升高，部分原因是循环中Na⁺-K⁺-ATP酶抑制剂浓度增加。
