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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Petty M A, Sitsen J M, De Jong W

Clin Sci (Lond). 1981 Dec;61 Suppl 7:339s-342s. doi: 10.1042/cs061339s.

The role of opiates in cardiovascular regulation has been investigated. 2. In urethane-anaesthetized renal hypertensive rats (two-kidney, one-clip Goldblatt model), intracerebroventricular beta-endorphin (10 microgram) caused a greater fall in mean arterial pressure than in sham-operated controls. 3. Unilateral injection of beta-endorphin into the nucleus tractus solitarii of the urethane-anaesthetized rat resulted in a U-shaped dose--response relationship, with a fall in mean arterial pressure and heart rate occurring at low doses. Doses above 10 ng caused a rise in pressure, accompanied by a variable effect on heart rate. 4. The fall in blood pressure and heart rate was prevented by prior subcutaneous administration of naloxone. Naloxone caused an increase in blood pressure when administered alone. 5. These results suggest a depressor role of an endogenous brain opiate, possibly beta endorphin; a site of action is probably the nucleus tractus solitarii.

阿片类药物在心血管调节中的作用已得到研究。2. 在氨基甲酸乙酯麻醉的肾性高血压大鼠（双肾一夹戈德布拉特模型）中，脑室内注射β-内啡肽（10微克）导致平均动脉压下降幅度大于假手术对照组。3. 向氨基甲酸乙酯麻醉大鼠的孤束核单侧注射β-内啡肽产生了U形剂量-反应关系，低剂量时平均动脉压和心率下降。剂量高于10纳克时导致血压升高，同时对心率有不同影响。4. 预先皮下注射纳洛酮可预防血压和心率下降。单独注射纳洛酮会导致血压升高。5. 这些结果提示内源性脑阿片类物质，可能是β-内啡肽，具有降压作用；作用部位可能是孤束核。

Petty M A, Sitsen J M, De Jong W

Clin Sci (Lond). 1981 Dec;61 Suppl 7:339s-342s. doi: 10.1042/cs061339s.

The role of opiates in cardiovascular regulation has been investigated. 2. In urethane-anaesthetized renal hypertensive rats (two-kidney, one-clip Goldblatt model), intracerebroventricular beta-endorphin (10 microgram) caused a greater fall in mean arterial pressure than in sham-operated controls. 3. Unilateral injection of beta-endorphin into the nucleus tractus solitarii of the urethane-anaesthetized rat resulted in a U-shaped dose--response relationship, with a fall in mean arterial pressure and heart rate occurring at low doses. Doses above 10 ng caused a rise in pressure, accompanied by a variable effect on heart rate. 4. The fall in blood pressure and heart rate was prevented by prior subcutaneous administration of naloxone. Naloxone caused an increase in blood pressure when administered alone. 5. These results suggest a depressor role of an endogenous brain opiate, possibly beta endorphin; a site of action is probably the nucleus tractus solitarii.

阿片类药物在心血管调节中的作用已得到研究。2. 在氨基甲酸乙酯麻醉的肾性高血压大鼠（双肾一夹戈德布拉特模型）中，脑室内注射β-内啡肽（10微克）导致平均动脉压下降幅度大于假手术对照组。3. 向氨基甲酸乙酯麻醉大鼠的孤束核单侧注射β-内啡肽产生了U形剂量-反应关系，低剂量时平均动脉压和心率下降。剂量高于10纳克时导致血压升高，同时对心率有不同影响。4. 预先皮下注射纳洛酮可预防血压和心率下降。单独注射纳洛酮会导致血压升高。5. 这些结果提示内源性脑阿片类物质，可能是β-内啡肽，具有降压作用；作用部位可能是孤束核。