Petty M A, de Jong W, de Wied D
Life Sci. 1983;33 Suppl 1:735-7. doi: 10.1016/0024-3205(83)90607-0.
Unilateral microinjection of gamma endorphin (1-17) into the nucleus tractus solitarii (NTS) of the urethane anaesthetised rat produces a dose-related pressor response. This effect has been examined in the present study, by means of fragments of the molecule. Unilateral application of the peptides 6-16, 10-16, 6-17 and 10-17 (1 ng) all produced an equivalent rise in blood pressure, however the time course of 6-16 and 10-16 was more rapid than that of gamma endorphin or the fragments containing the 17th amino acid. Naloxone (10 ng) administered into the NTS, did not affect the maximum rise in pressure induced by 6-17 (1 ng). It is concluded that in addition to a depressor region, which is dependent on the N-terminal tyrosine, the beta endorphin molecule (1-31) also has a pressor region, which is present within the amino acid sequence 10-16, and is a non-opiate effect.
向经乌拉坦麻醉的大鼠孤束核（NTS）单侧微量注射γ-内啡肽（1-17）会产生剂量相关的升压反应。在本研究中，通过该分子的片段对这种效应进行了研究。单侧应用肽6-16、10-16、6-17和10-17（1纳克）均使血压产生同等程度的升高，然而6-16和10-16的作用时程比γ-内啡肽或含第17个氨基酸的片段更快。向NTS注射纳洛酮（10纳克），并不影响6-17（1纳克）诱导的最大血压升高。得出的结论是，除了依赖于N端酪氨酸的降压区域外，β-内啡肽分子（1-31）还具有一个升压区域，该区域存在于氨基酸序列10-16内，并且是一种非阿片样效应。
