Ashton D, Wauquier A
Eur J Pharmacol. 1981 Oct 15;75(1):71-4. doi: 10.1016/0014-2999(81)90348-4.
The preferential alpha 2-noradrenergic agonist clonidine dose-relatedly increased the onset of seizures and mortality times, and decreased severity in rats treated with D,L-allylglycine. These effects were reduced by a dose (2.5 mg/kg) of the preferential alpha 2-antagonist yohimbine, which was itself inactive on the allylglycine seizures. Yohimbine 10 mg/kg alone decreased onset and mortality times. The preferential alpha 1-antagonist prazosin had a slight anticonvulsant effect. These results suggest that the reduction of NA release at alpha 2-noradrenergic receptors or antagonism of noradrenaline effects at alpha 1-receptors exerts seizure suppressant effects.
选择性α2-去甲肾上腺素能激动剂可乐定剂量依赖性地增加了用D，L-烯丙基甘氨酸处理的大鼠的癫痫发作起始时间和死亡时间，并降低了严重程度。这些作用被剂量为2.5mg/kg的选择性α2-拮抗剂育亨宾减弱，而育亨宾本身对烯丙基甘氨酸诱发的癫痫发作无作用。单独使用10mg/kg育亨宾可缩短发作起始时间和死亡时间。选择性α1-拮抗剂哌唑嗪有轻微的抗惊厥作用。这些结果表明，α2-去甲肾上腺素能受体处去甲肾上腺素释放的减少或α1-受体处去甲肾上腺素作用的拮抗发挥了癫痫抑制作用。
