用胡宁病毒对小鼠巨噬细胞进行体外感染。
In vitro infection of murine macrophages with Junin virus.
作者信息
González P H, Lampuri J S, Coto C E, Laguens R P
出版信息
Infect Immun. 1982 Jan;35(1):356-8. doi: 10.1128/iai.35.1.356-358.1982.
Abstract
Mouse peritoneal macrophages were successfully infected with two strains of Junin virus producing high titers with no apparent cell damage. Infected cultures survived longer than noninfected cultures. The pattern of virus release suggested a persistent infection. Virus replication was delayed in macrophages from mice previously immunized with Junin virus. These results support the opinion that macrophages are targets for virus replication in vivo infections.
摘要
两株胡宁病毒成功感染了小鼠腹腔巨噬细胞，产生了高滴度的病毒且没有明显的细胞损伤。被感染的培养物比未感染的培养物存活时间更长。病毒释放模式表明存在持续性感染。在先前用胡宁病毒免疫过的小鼠的巨噬细胞中，病毒复制被延迟。这些结果支持巨噬细胞是体内感染中病毒复制靶标的观点。
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