Caniggia A, Nuti R, Galli M
J Endocrinol Invest. 1981 Jul-Sep;4(3):281-7. doi: 10.1007/BF03349445.
24-h urinary cyclic adenosine 3', 5'-monophosphate/creatinine (cAMP/Cr) ratio was assessed in 10 patients with hypoparathyroidism, 6 with primary hyperparathyroidism, 7 with normocalcemic hypercalciuria and recurrent nephrolithiasis, 14 with osteomalacia, 25 with Paget's disease and 53 with symptomatic postmenopausal osteoporosis. In hypoparathyroid subjects the mean values of 24 h cAMP/Cr ratio were significantly lower than the control values, whereas in patients with parathyroid adenoma the mean values were higher and fell after parathyroid surgery. Patients with nephrolithiasis due to absorptive hypercalciuria showed low or normal cAMP/Cr ratio, whereas in those with osteomalacia and mean values of cAMP/Cr ratio were significantly higher than the control values and decreased after vitamin D treatment. The mean value of the 24 h urine cAMP/Cr ratio was normal in patients with Paget's disease or postmenopausal osteoporosis and increased significantly after long term treatment with calcitonin or diphosphonate. This increase paralleled a significant decrease of calcium plasma level. A significant improvement of fractional calcium absorption was observed in women with postmenopausal osteoporosis at the end of treatment with calcitonin or diphosphonate.
对10例甲状旁腺功能减退患者、6例原发性甲状旁腺功能亢进患者、7例血钙正常性高钙尿症合并复发性肾结石患者、14例骨软化症患者、25例佩吉特病患者以及53例有症状的绝经后骨质疏松症患者测定了24小时尿中环磷酸腺苷/肌酐（cAMP/Cr）比值。甲状旁腺功能减退患者24小时cAMP/Cr比值的平均值显著低于对照值，而甲状旁腺腺瘤患者的平均值较高，甲状旁腺手术后下降。因吸收性高钙尿症导致肾结石的患者cAMP/Cr比值较低或正常，而骨软化症患者cAMP/Cr比值的平均值显著高于对照值，维生素D治疗后降低。佩吉特病或绝经后骨质疏松症患者24小时尿cAMP/Cr比值的平均值正常，长期使用降钙素或双膦酸盐治疗后显著升高。这种升高与血浆钙水平的显著降低平行。在绝经后骨质疏松症女性患者接受降钙素或双膦酸盐治疗结束时，观察到钙吸收分数有显著改善。
