Robinson N E, Sorenson P R
J Appl Physiol Respir Environ Exerc Physiol. 1978 Jan;44(1):63-8. doi: 10.1152/jappl.1978.44.1.63.
We studied collateral flow resistance in exsanguinated, excised lower lobes and accessory lobes of dog and horse lungs, respectively. A double lumen catheter obstructed a peripheral airway isolating a segment of the lobe. Oxygen flowed into the segment via a rotameter which measured flow (Vcoll) while the inner catheter recorded segment pressure (Ps). Gas delivered into the segment flowed out via collateral channels. Collateral flow resistance was calculated as (Ps - PL)/Vcoll, where PL = static transpulmonary pressure. Rcoll at PL = 20, 10, and 5 cm H2O averaged 0.24, 1.25, and 2.65 cmH2O.ml-1.s, respectively, in the dog, and 4.53, 6.00, and 12.62 cmH2O.ml-1.s in the horse. At a given PL, Rcoll measured during inflation. At constant PL, Rcoll increased with time at PL = 5 and 10 cmH2O, but was not time dependent at PL = 20 cmH2O. At constant PL, Rcoll increased at Vcoll increased. We conclude Rcoll is greater in horses than in dogs and is a function of PL, Ps - PL, and lung volume history in both species.
我们分别研究了犬和马肺的放血后离体下叶及副叶中的侧支血流阻力。一根双腔导管阻塞一条外周气道，从而隔离肺叶的一个节段。氧气通过一个测量流量（Vcoll）的转子流量计流入该节段，同时内部导管记录节段压力（Ps）。输送到该节段的气体通过侧支通道流出。侧支血流阻力计算为（Ps - PL）/Vcoll，其中PL = 静态跨肺压。在犬中，当PL分别为20、10和5 cm H2O时，Rcoll平均分别为0.24、1.25和2.65 cmH2O·ml-1·s，在马中分别为4.53、6.00和12.62 cmH2O·ml-1·s。在给定的PL下，Rcoll在充气过程中进行测量。在PL恒定的情况下，在PL = 5和10 cmH2O时，Rcoll随时间增加，但在PL = 20 cmH2O时与时间无关。在PL恒定的情况下，Rcoll随Vcoll增加而增加。我们得出结论，马的Rcoll比犬的大，并且在这两个物种中，Rcoll都是PL、Ps - PL和肺容积变化过程的函数。
