2型腺病毒晚期基因在感染2型腺病毒或2型腺病毒-猴病毒40杂交病毒的HeLa细胞中的表达。
Expression of adenovirus type 2 late genes in HeLa cells infected with adenovirus type 2 or adenovirus type 2-simian virus 40 hybrid viruses.
作者信息
Lawrence C B
出版信息
J Virol. 1981 Nov;40(2):610-4. doi: 10.1128/JVI.40.2.610-614.1981.
Abstract
The relative levels of expression of the five 3'-coterminal mRNA families encode in the 16.4 to 99 map unit transcription unit of adenovirus type 2 (Ad2) are determined in part by the frequency of utilization of five possible polyadenylation sites. The possibility that polyadenylation frequencies at these sites may be regulated was tested by examining the expression of the fiber (polypeptide IV) gene in cells infected with nondefective (ND) Ad2-simian virus 40 hybrid viruses which express a sixth late mRNA family. Both the relative rate of fiber protein synthesis and the relative abundance of fiber mRNA were normal in cells infected with the hybrid viruses Ad2+ND1, Ad2+ND2, or Ad2+ND4.
摘要
在2型腺病毒（Ad2）16.4至99图单位转录单位中编码的五个3' 共末端mRNA家族的相对表达水平，部分由五个可能的聚腺苷酸化位点的使用频率决定。通过检测纤维（多肽IV）基因在感染了表达第六个晚期mRNA家族的无缺陷（ND）Ad2-猴病毒40杂交病毒的细胞中的表达，来测试这些位点处聚腺苷酸化频率可能受到调控的可能性。在感染杂交病毒Ad2+ND1、Ad2+ND2或Ad2+ND4的细胞中，纤维蛋白合成的相对速率和纤维mRNA的相对丰度均正常。
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本文引用的文献
1
Identification of the gene and mRNA for the adenovirus terminal protein precursor.
Cell. 1981 Feb;23(2):497-508. doi: 10.1016/0092-8674(81)90145-8.
2
Transcripts from the adenovirus-2 major late promoter yield a single early family of 3' coterminal mRNAs and five late families.
Cell. 1980 Dec;22(3):905-16. doi: 10.1016/0092-8674(80)90568-1.
3
Size heterogeneity in the 3' end of dihydrofolate reductase messenger RNAs in mouse cells.
Cell. 1980 Nov;22(2 Pt 2):361-70. doi: 10.1016/0092-8674(80)90346-3.
4
Multiple mRNA species for adenovirus type 2 polypeptides III and pVII.
J Virol. 1980 Aug;35(2):306-13. doi: 10.1128/JVI.35.2.306-313.1980.
5
Transcription units of adenovirus type 2. Termination of transcription beyond the poly(A) addition site in early regions 2 and 4.
J Mol Biol. 1980 Dec 15;144(3):377-86. doi: 10.1016/0022-2836(80)90096-0.
6
Regulation of adenovirus-2 gene expression at the level of transcriptional termination and RNA processing.
Nature. 1981 Mar 12;290(5802):113-8. doi: 10.1038/290113a0.
7
The primary transcription unit of the mouse beta-major globin gene.
Cell. 1981 Feb;23(2):585-93. doi: 10.1016/0092-8674(81)90154-9.
8
Two mRNAs can be produced from a single immunoglobulin mu gene by alternative RNA processing pathways.
Cell. 1980 Jun;20(2):313-9. doi: 10.1016/0092-8674(80)90617-0.
9
Synthesis of secreted and membrane-bound immunoglobulin mu heavy chains is directed by mRNAs that differ at their 3' ends.
Cell. 1980 Jun;20(2):293-301. doi: 10.1016/0092-8674(80)90615-7.
10
Specific fragmentation of DNA of adenovirus serotypes 3, 5, 7, and 12, and adeno-simian virus 40 hybrid virus Ad2+ND1 by restriction endonuclease R.EcoRI.
J Virol. 1974 Jul;14(1):68-77. doi: 10.1128/JVI.14.1.68-77.1974.
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