Kerdelhué B, Bethea C L, Ling N, Chrétien M, Weiner R I
Brain Res. 1982 Jan 7;231(1):85-91. doi: 10.1016/0006-8993(82)90009-9.
The serum and brain concentrations of beta-endorphin immunoreactivity have been studied in intact, mediobasal hypothalamus (MBH) lesioned and hypophysectomized male rats. After hypophysectomy there is a major reduction (90%) of beta-endorphin concentration in the serum but only a partial reduction (20%) in the mediobasal hypothalamus. However, MBH lesions enhance beta-endorphin serum values in previously hypophysectomized rats. Long-term MBH lesions alone lead to an almost complete disappearance of beta-endorphin in the central gray matter with a slight decrease in the serum. These data clearly show that: (1) the pituitary is the major source of beta-endorphin in the serum; (2) the hypothalamus is the major source of beta-endorphin in the central gray matter; and (3) there is clear influence of the pituitary on hypothalamic beta-endorphin.
在完整、中基底下丘脑（MBH）损伤及垂体切除的雄性大鼠中，研究了β-内啡肽免疫反应性的血清和脑内浓度。垂体切除后，血清中β-内啡肽浓度大幅降低（90%），但中基底下丘脑仅部分降低（20%）。然而，MBH损伤可提高先前垂体切除大鼠的β-内啡肽血清值。单独的长期MBH损伤会导致中央灰质中β-内啡肽几乎完全消失，血清中略有下降。这些数据清楚地表明：（1）垂体是血清中β-内啡肽的主要来源；（2）下丘脑是中央灰质中β-内啡肽的主要来源；（3）垂体对下丘脑β-内啡肽有明显影响。
