降压药对家兔水负荷后眼压的影响。
The effect of hypotensive drugs on the intraocular pressure after waterloading in rabbits.
作者信息
van Bijsterveld O P, van Loenen A C, ten Ham M
出版信息
Doc Ophthalmol. 1981 Dec 16;52(2):189-98. doi: 10.1007/BF01675205.
The waterloading test in rabbits, using 100 ml of waterloads per kg body weight, without general anaesthesia and with applanation tonometry to measure intraocular pressure (IOP), deserves a place in glaucoma research. Using this model we found adrenaline not to have an effect on the IOP with or without waterloading. Isoprenaline and to a lesser physostigmine reduced the pressure in the normal eye markedly, but these drugs did not have any effect on the pressure after waterloading. delta 9-THC (Tetrahydrocannabinol) and pilocarpine increased the IOP in the normal rabbit eye. After waterloading delta 9-THC decreased the pressure, but its value was still significantly higher than the control pressure. Pilocarpine did not reduce the pressure after waterloading. Acetazolamide and timolol did not reduce the pressure in the normal eye, but after waterloading a significant reduction was observed.
在家兔身上进行水负荷试验，每千克体重给予100毫升水负荷，不进行全身麻醉，采用压平眼压计测量眼压（IOP），该试验在青光眼研究中值得占有一席之地。使用这个模型，我们发现无论有无水负荷，肾上腺素对眼压均无影响。异丙肾上腺素和毒扁豆碱（程度较轻）能显著降低正常眼的眼压，但这些药物对水负荷后的眼压没有任何影响。δ9-四氢大麻酚（THC）和毛果芸香碱可使正常兔眼的眼压升高。水负荷后，δ9-THC可降低眼压，但其值仍显著高于对照眼压。水负荷后毛果芸香碱不能降低眼压。乙酰唑胺和噻吗洛尔在正常眼中不能降低眼压，但水负荷后眼压显著降低。
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