de Castro J M, Stoerzinger A, Barkmeier D, Ellen P
J Comp Physiol Psychol. 1978 Feb;92(1):71-84. doi: 10.1037/h0077443.
The microregulatory patterns of food and water intake were examined in male and female rats bearing medical septal lesions and in sham-operated controls. Medial septal ablation, although not affecting the total amount of food or water ingested, resulted in a profound disruption of the pattern of intake. Circadian rhythmicity was disrupted for a period, returning to normal by 25 days postlesion. Permanent disruptions occurred in feeding patterns in the rats with septal lesions ingested more frequent but smaller meals. There was also a marked increase in food-intake-associated drinking and a decrease in non-food-intake-associated drinking. The results are interpreted to reflect two separate independent effects, a general circadian disruption and an alteration in requlatory behavior produced by a chronic depletion of body fluid.
对患有内侧隔损伤的雄性和雌性大鼠以及假手术对照组的食物和水摄入的微观调节模式进行了研究。内侧隔消融术虽然不影响摄入的食物或水的总量，但导致摄入模式的严重紊乱。昼夜节律在一段时间内被打乱，损伤后25天恢复正常。内侧隔损伤大鼠的进食模式出现永久性紊乱，它们进食更频繁但量更小。与食物摄入相关的饮水也显著增加，与非食物摄入相关的饮水减少。这些结果被解释为反映了两种独立的影响，一种是一般的昼夜节律紊乱，另一种是由于体液长期消耗导致的调节行为改变。
