Iovino M, Monteleone P, Papa M, Amoruso A, Steardo L
Department of Neurology, 2nd Medical School, University of Naples, Italy.
Neurosci Res. 1988 Oct;6(1):76-82. doi: 10.1016/0168-0102(88)90008-9.
The intraseptal administration of the neurotoxin kainic acid (KA) induced a significant depletion of the neuronal population and glial proliferation in medial septal areas. The behavioral effects induced by this selective destruction of the neurons indigenous to the medial septal areas were investigated. KA produced a marked increase in urine output and a transient reduction in body weight, but failed to affect water and food intake.
向中隔内注射神经毒素红藻氨酸（KA）可导致中隔内侧区域的神经元数量显著减少和胶质细胞增生。研究了这种对中隔内侧区域固有神经元的选择性破坏所引发的行为效应。KA使尿量显著增加，体重短暂下降，但对水和食物摄入量没有影响。
