Riepenhoff-Talty M, Bogger-Goren S, Li P, Carmody P J, Barrett H J, Ogra P L
J Med Virol. 1981;8(3):215-22. doi: 10.1002/jmv.1890080309.
The temporal characteristics of the response of rotavirus specific IgM, IgG, IgA in serum and secretory antibody in feces to rotavirus were studied in 77 hospitalized patients with rotavirus induced gastroenteritis. The response in serum was characterized by the sequential appearance of rotavirus specific IgM, IgG, and IgA antibody. The IgM antibody appeared to be higher in the acute phase of the disease and was subsequently replaced by the IgG and IgA antibodies. However, the titers of IgG rotavirus antibody in convalescent specimens of serum were found to be statistically significantly lower in patients with severe or prolonged rotavirus infection than in specimens from subjects with mild or moderate disease. Most fecal specimens collected during both the acute and convalescent phase of illness contained virus specific secretory IgA. Higher concentrations of antibody were measured in convalescent samples from patients with prolonged diarrhea and virus shedding. These observations suggest a possible relationship between the severity of rotavirus infection and the nature of systemic and secretory antibody response.
对77例住院的轮状病毒感染性胃肠炎患者血清中轮状病毒特异性IgM、IgG、IgA及粪便中分泌性抗体对轮状病毒反应的时间特征进行了研究。血清中的反应特点是轮状病毒特异性IgM、IgG和IgA抗体依次出现。IgM抗体在疾病急性期似乎较高，随后被IgG和IgA抗体取代。然而，发现重度或长期轮状病毒感染患者血清恢复期标本中IgG轮状病毒抗体滴度在统计学上显著低于轻度或中度疾病患者的标本。在疾病急性期和恢复期采集的大多数粪便标本中都含有病毒特异性分泌型IgA。腹泻时间延长和病毒持续排出患者的恢复期样本中检测到更高浓度的抗体。这些观察结果提示轮状病毒感染的严重程度与全身和分泌性抗体反应的性质之间可能存在关联。
