多溴联苯对大鼠肝脏微粒体雌激素代谢及所给予雌激素子宫促生长作用的影响。
Effect of polybrominated biphenyls on hepatic microsomal metabolism of estrogens and uterotropic action of administered estrogen in rats.
作者信息
Bonhaus D W, McCormack K M, Braselton W E, Hook J B
出版信息
J Toxicol Environ Health. 1981 Jul-Aug;8(1-2):141-50. doi: 10.1080/15287398109530058.
PMID:6276575
Abstract
Perinatal exposure to polybrominated biphenyls (PBBs) increased the hepatic microsomal metabolism of estradiol, estrone, and ethynylestradiol in vitro. Pretreatment with PBBs decreased the effect of estradiol administered exogenously on uterine estrogen cytosolic receptor concentration. The effect of exogenous estradiol on uterine weight and uterine RNA content was also reduced by perinatal exposure to PBBs. Therefore, metabolism of estrogens is altered by PBBs.
摘要
围产期暴露于多溴联苯（PBBs）会在体外增加雌二醇、雌酮和乙炔雌二醇的肝微粒体代谢。用PBBs进行预处理会降低外源性给予的雌二醇对子宫雌激素胞质受体浓度的影响。围产期暴露于PBBs也会降低外源性雌二醇对子宫重量和子宫RNA含量的影响。因此，PBBs会改变雌激素的代谢。
Zotero 插件