[Diuretics and uric acid (author's transl)].

Long-term diuretic therapy often increases serum uric acid. The renal metabolism of uric acid is recalled and the factors which lead to diuretic-induced hyperuricemia are discussed. Fluid and sodium loss appears to be the main cause of increased serum uric acid. The authors' experience with management of severe hypertension is consistent with this theory. The effect of tienilic acid which lowers serum uric acid levels is discussed.