Malý J, Nádvorníková H, Schück O
Int J Clin Pharmacol Ther Toxicol. 1982 Jan;20(1):44-6.
Our study was conducted in two groups of subjects with normal renal function and with normal metabolism of uric acid. Findings showed that the administration of prednisone (Group 1) results in increased renal excretion of uric acid. The observed significant increases in the renal clearance and fractional excretion of uric acid were not associated with any significant alterations in its plasma level. Further, our study did not confirm any effect of azathioprine (Imuran) (Group 2) on renal uric acid excretion, but its administration led to a significant reduction of its plasma level. Imuran appears to act on the metabolism of uric acid extrarenally.
我们的研究在两组肾功能正常且尿酸代谢正常的受试者中进行。研究结果表明，给予泼尼松（第1组）会导致尿酸的肾脏排泄增加。观察到的尿酸肾脏清除率和排泄分数的显著增加与血浆水平的任何显著变化无关。此外，我们的研究未证实硫唑嘌呤（依木兰）（第2组）对肾脏尿酸排泄有任何影响，但其给药导致血浆水平显著降低。依木兰似乎在肾脏外作用于尿酸代谢。
