Jean R, Rolin B
Sem Hop. 1982 Jan 14;58(2):123-6.
At the present, prognosis of insulin-dependent diabetes depends on it's degenerative complications. Many studies have confirmed that the incidence of severe degenerative complications of early onset parallels the degree of metabolic unbalance. Unfortunately, in many diabetic patients satisfactory metabolic control is difficult to ensure because of the irregular absorption of insulin injected discontinuously in subcutaneous tissues. This is true even under strict diet conditions. Continuous insulin infusion at a predetermined dosage was therefore suggested. Data on basic requirements is provided by an artificial pancreas. Satisfactory results have already been reported with intravenous and subcutaneous routes. Intramuscular and intraperitoneal routes are at present under trial. The use of portable pumps facilitates these techniques. The insulin dosage must be correctly determined and adjusted to the patient's diet and activity. In brittle diabetes, these methods can provide, at least temporarily, a satisfactory metabolic balance, and useful data for adjusting further therapy.
目前，胰岛素依赖型糖尿病的预后取决于其退行性并发症。许多研究证实，早发型严重退行性并发症的发生率与代谢失衡程度平行。不幸的是，在许多糖尿病患者中，由于皮下组织中胰岛素注射不连续导致吸收不规则，难以确保令人满意的代谢控制。即使在严格的饮食条件下也是如此。因此，有人建议以预定剂量持续输注胰岛素。人工胰腺可提供关于基本需求的数据。静脉和皮下途径已报告取得了满意的结果。肌肉内和腹腔内途径目前正在试验中。便携式泵的使用促进了这些技术。胰岛素剂量必须正确确定，并根据患者的饮食和活动进行调整。在脆性糖尿病中，这些方法至少可以暂时提供令人满意的代谢平衡，并为调整进一步治疗提供有用的数据。
