Vose G P, Keele D K, Milner A M, Rawley R, Roach T L, Sprinkle E E
J Gerontol. 1978 Mar;33(2):204-12. doi: 10.1093/geronj/33.2.204.
Elderly osteoporotic males treated with sodium fluoride or inorganic phosphate for 4 years plus 2 years of follow-up observations exhibited a mean but not significant decrease in the rate of bone mass loss in comparison with those receiving oxymetholone or a placebo. No hip fractures occurred in the patients who received fluoride, while 11 hip fractures occurred in the patients in the phosphate, oxymetholone, and control groups. Because the densitometric trends and fracture incidence are impressive, the progress of all subjects will be followed for an additional 4 years.
接受氟化钠或无机磷酸盐治疗4年并进行2年随访观察的老年骨质疏松男性，与接受羟甲烯龙或安慰剂的男性相比，骨量流失率平均有所下降，但差异不显著。接受氟化物治疗的患者未发生髋部骨折，而磷酸盐、羟甲烯龙和对照组的患者发生了11例髋部骨折。由于骨密度测量趋势和骨折发生率令人印象深刻，所有受试者的情况将再随访4年。
