Pachner A R, Kantor F S
Ann Neurol. 1982 Jan;11(1):48-52. doi: 10.1002/ana.410110109.
Use of the mouse model of myasthenia gravis (murine EAMG), ideally suited for immunological study, has been hampered by the relatively mild character of the disease and by the extended time and effort required for inducing severe disease. Electromyographic measurement of the compound action potential after repetitive stimuli, the nerve stimulation test, was evaluated for its ability to diagnose neuromuscular transmission defects in mice immunized with Torpedo acetylcholine receptor. With the combination of provocative maneuvers and raising of the body temperature, EAMG could be diagnosed in nearly all immunized animals a few weeks after immunization, whereas clinical evaluation of muscle weakness was positive in less than half of immunized mice months after the first immunization. Thus, EMG provides a means of objective evaluation of the disease and attempts at its experimental modification.
重症肌无力小鼠模型（鼠类实验性自身免疫性重症肌无力，EAMG）非常适合用于免疫学研究，但该疾病相对较轻的特征以及诱导严重疾病所需的较长时间和精力阻碍了其应用。对用鱼雷乙酰胆碱受体免疫的小鼠进行重复刺激后复合动作电位的肌电图测量，即神经刺激试验，以评估其诊断神经肌肉传递缺陷的能力。通过激发性操作和提高体温相结合的方法，在免疫后几周几乎可以在所有免疫动物中诊断出EAMG，而在首次免疫数月后，不到一半的免疫小鼠的肌肉无力临床评估呈阳性。因此，肌电图提供了一种客观评估该疾病及其实验性改良尝试的方法。
