Miyahara S, Oomura Y
Brain Res. 1982 Feb 25;234(2):459-63. doi: 10.1016/0006-8993(82)90887-3.
Electrical stimulation of the ventral noradrenergic bundle (V-NA bundle) produced 3 types of responses in lateral hypothalamic neurons: IPSPs, a polysynaptic EPSP-IPSP sequence and antidromic spikes. The IPSPs were considered to be monosynaptic due to the fixed latencies seen at stimulus intensities. Iontophoretic application of an alpha-NA antagonist blocked only the presumed monosynaptic inhibition. Most of the glucose-sensitive neurons were inhibited by stimulation of the V-NA bundle. These results may account for the hyperphagia and obesity produced by selective lesions of the V-NA bundle.
对腹侧去甲肾上腺素能束（V-NA束）进行电刺激，在下丘脑外侧神经元中产生了3种类型的反应：抑制性突触后电位（IPSPs）、多突触兴奋性突触后电位-抑制性突触后电位序列以及逆向动作电位。由于在刺激强度下观察到固定的潜伏期，IPSPs被认为是单突触的。离子电泳应用α-去甲肾上腺素拮抗剂仅阻断了推测的单突触抑制。大多数葡萄糖敏感神经元受到V-NA束刺激的抑制。这些结果可能解释了V-NA束选择性损伤所产生的摄食过多和肥胖现象。
