Shiraishi T
Department of Physiology, Tokai University School of Medicine, Bohseidai Isehara, Japan.
Brain Res Bull. 1991 Sep-Oct;27(3-4):347-51. doi: 10.1016/0361-9230(91)90123-2.
The lateral hypothalamus (LHA) is important in feeding behavior. Functions of neurotransmitters and receptors in the control of feeding behavior elicited by electrical and chemical stimulation in the bilateral LHA were studied using electrodes and cannulae chronically implanted in sated rats. Experiments were performed in the daylight (0700-1900). Chemical stimulation with norepinephrine (NE), epinephrine (E) or dopamine (DA) dose-dependently (1-10 nmol) increased food intake (g/8 h). Neither E nor DA affected LHA-electrical stimulation-induced feeding (ESIF), but small doses (0.5-10 nmol) of NE significantly (p less than 0.05) enhanced LHA-ESIF. Pretreatment with larger doses (50-500 nmol) of NE significantly (p less than 0.05-0.01) inhibited LHA-ESIF. The results indicate that catecholaminergic input to feeding-related neurons in the LHA is noradrenergic. Pretreatment with 10-160 nmol phenoxybenzamine (PBZ) or 5-80 nmol propranolol (PNL) dose-dependently inhibited ESIF. PBZ was slightly more potent than PNL, which indicates that the feeding-related adrenergic receptors in the LHA are predominantly alpha-receptors. Electrophysiological data support these behavioral results which, when taken together, suggest that LHA-ESIF might be caused by electrically driven release of NE from feeding-related neurons.
外侧下丘脑（LHA）在进食行为中起着重要作用。利用长期植入饱腹大鼠体内的电极和套管，研究了双侧LHA中神经递质和受体在电刺激和化学刺激引发的进食行为控制中的功能。实验在白天（07:00 - 19:00）进行。用去甲肾上腺素（NE）、肾上腺素（E）或多巴胺（DA）进行化学刺激（1 - 10 nmol）时，食物摄入量呈剂量依赖性增加（克/8小时）。E和DA均不影响LHA电刺激诱导的进食（ESIF），但小剂量（0.5 - 10 nmol）的NE显著（p小于0.05）增强了LHA - ESIF。用较大剂量（50 - 500 nmol）的NE预处理显著（p小于0.05 - 0.01）抑制了LHA - ESIF。结果表明，LHA中与进食相关神经元的儿茶酚胺能输入是去甲肾上腺素能的。用10 - 160 nmol的酚苄明（PBZ）或5 - 80 nmol的普萘洛尔（PNL）预处理呈剂量依赖性抑制ESIF。PBZ的作用略强于PNL，这表明LHA中与进食相关的肾上腺素能受体主要是α受体。电生理数据支持这些行为学结果，综合来看，提示LHA - ESIF可能是由与进食相关神经元电驱动释放NE所引起的。
