Asano T, Ogasawara N
Eur J Pharmacol. 1982 Feb 5;77(4):355-7. doi: 10.1016/0014-2999(82)90144-3.
Barbiturates increase Na+-independent GABA binding to bovine cerebral cortex membranes. The relative activity of a series of compounds to enhance GABA binding correlates significantly with their anesthetic activity and with their ability to reverse bicuculline antagonism of GABA responses. There are regional differences in the maximal percent stimulation of GABA binding by pentobarbital; a low stimulation in cerebellum.
巴比妥类药物可增加牛脑皮层膜上不依赖钠离子的γ-氨基丁酸（GABA）结合。一系列化合物增强GABA结合的相对活性与其麻醉活性以及逆转荷包牡丹碱对GABA反应的拮抗作用的能力显著相关。戊巴比妥对GABA结合的最大刺激百分比存在区域差异；在小脑中刺激程度较低。
