Ninomiya K, Hasegawa Y, Hamaya K, Masuda K, Nishio T
Jpn J Antibiot. 1981 Nov;34(11):1477-84.
A fundamental and clinical study of ceftizoxime (CZX), a new cephalosporin antibiotic, has brought about the following results. 1. The antibacterial activity of CZX against Bacteriodes fragilis and B. thetaiotaomicron was superior to that of CEZ, but inferior to that of CFX. CZX was the most active of the 3 drugs against B. distasonis, and was as active as CFX against B. vulgatus. The MICs of CZX against Peptococcus, Peptostreptococcus and anaerobic Streptococcus were 1.56 microgram/ml or lower. CEZ was more active than CZX against these anaerobic cocci. 2. The concentrations of CZX in female genital organs and retroperitoneal dead space exudate after drip infusion of 1 g were high enough to fulfill the MICs of many bacterial isolates. 3. CZX administered intravenously to 9 patients in daily doses of 1 approximately 8 g for 4 approximately 11 days was 100% effective. Pathogenic bacteria in 6 of the patients were eradicated in 4 and partially eradicated in 1. The other patient had no bacteriological examination after therapy. 4. No adverse reaction was observed. From above results it is concluded that CZX must be one of the most effective antibiotics for the treatment of gynecological infections.
对新型头孢菌素抗生素头孢唑肟（CZX）进行的基础和临床研究得出了以下结果。1. CZX对脆弱拟杆菌和多形拟杆菌的抗菌活性优于头孢乙腈（CEZ），但低于头孢西丁（CFX）。CZX对解脲拟杆菌的抗菌活性在这三种药物中最强，对普通拟杆菌的抗菌活性与CFX相当。CZX对消化球菌、消化链球菌和厌氧链球菌的最低抑菌浓度（MIC）为1.56微克/毫升或更低。CEZ对这些厌氧球菌的抗菌活性比CZX更强。2. 静脉滴注1克CZX后，女性生殖器官和腹膜后死腔渗出液中的药物浓度足以达到许多细菌分离株的MIC。3. 对9例患者静脉注射CZX，日剂量为1至8克，疗程为4至11天，有效率达100%。6例患者中的病原菌有4例被根除，1例被部分根除。另1例患者治疗后未进行细菌学检查。4. 未观察到不良反应。根据上述结果得出结论，CZX必定是治疗妇科感染最有效的抗生素之一。
