Ninomiya K, Hasegawa Y, Hamatani K, Nishio T
Jpn J Antibiot. 1981 Apr;34(4):507-14.
Fundamental and clinical studies of cefotaxime (CTX), a new semisynthetic cephalosporin antibiotic were carried out in the field of obstetrics and gynecology. The following results were obtained. 1. CTX was almost equally active to SCE-1365 and less active than cefotiam (CTM) and cefazolin (CEZ) against S. aureus, much more active than these 3 antibiotics against E. coli, more active than the 3 antibiotics against Enterobacter, equally active to SCE-1365 and a little weaker than CEZ against anaerobic Gram positive cocci, and superior to SCE-1365 and CEZ against Bacteroides. 2. CTX was more stable to B. fragilis-producing beta-lactamase than CET, CEZ and cefoperazone (CPZ). 3. The concentrations of CTX transferred to the female genital organs after CTX 1 g d. i. were sufficiently effective against facultative or strict anaerobic bacteria mainly isolated from obstetrical and gynecological infections. 4. CTX was administered to 10 patients with genital infections. CTX was excellent in 1 case, good in 8 cases and poor in 1 case. The response rate of CTX was 90%. Bacteria, isolated in 5 cases before CTX treatment, were eradicated in 4 cases. The bacteriological effectiveness of CTX was thus 80%. 5. No side effect attributable to CTX was observed.
对新型半合成头孢菌素抗生素头孢噻肟（CTX）进行了妇产科领域的基础和临床研究。获得了以下结果。1. CTX对SCE - 1365的活性几乎相同，对金黄色葡萄球菌的活性低于头孢替安（CTM）和头孢唑林（CEZ），对大肠杆菌的活性比这三种抗生素高得多，对肠杆菌的活性比这三种抗生素高，对厌氧革兰氏阳性球菌的活性与SCE - 1365相同且比CEZ稍弱，对拟杆菌的活性优于SCE - 1365和CEZ。2. CTX对脆弱拟杆菌产生的β - 内酰胺酶比头孢噻吩（CET）、CEZ和头孢哌酮（CPZ）更稳定。3. 每日1克CTX给药后转移至女性生殖器官的CTX浓度对主要从妇产科感染中分离出的兼性或严格厌氧菌有足够的疗效。4. 对10例生殖器感染患者使用了CTX。CTX疗效优秀的1例，良好的8例，差的1例。CTX的有效率为90%。CTX治疗前5例分离出的细菌，4例被根除。因此，CTX的细菌学有效率为80%。5. 未观察到归因于CTX的副作用。
