Carette B, Poulain P
Regul Pept. 1982 Feb;3(2):125-33. doi: 10.1016/0167-0115(82)90089-1.
Iontophoretic application of enkephalins induced inhibitory effects on unit activity of endocrine and adjacent neurones in the preoptic-septal region. Antagonism or lack of antagonism of these effects by naloxone indicated an action of enkephalins through different opiate receptors. Inhibitory effects of enkephalins were obtained during iontophoretic application of Mg2+, showing that these opioid peptides acted postsynaptically. Because enkephalin acts on endocrine neurones, these opioid peptides might be involved in the control of gonadotrophic hormone release by acting on cell bodies of LH-RH neurones.
脑啡肽的离子导入应用对视前 - 隔区的内分泌神经元和相邻神经元的单位活动产生抑制作用。纳洛酮对这些作用的拮抗或无拮抗作用表明脑啡肽通过不同的阿片受体起作用。在Mg2 +离子导入应用期间获得了脑啡肽的抑制作用，表明这些阿片肽在突触后起作用。由于脑啡肽作用于内分泌神经元，这些阿片肽可能通过作用于促黄体生成素释放激素（LH - RH）神经元的细胞体参与促性腺激素释放的控制。
