Justrabo E, Mergey E, Piard F, Michiels R, Viard H
Sem Hop. 1982 Mar 18;58(11):673-7.
The benign clear cell tumor of the lung is an uncommon neoplasm. It is often confused, before histological analysis, with metastases. The data of one personal observation are similar to those of 19 other cases of the literature. This tumor which occurs with an equal frequency in adults of the two sexes is often asymptomatic. It is discovered after a systematic x-ray control of the lungs. It is located in the peripheral parenchyma and looks like a round, homogeneous, well delimited opacity. Its evolution is always favourable after surgical excision. The benign clear cell tumour is never identified before pathological study. This neoplasm 1 to 6 cm in diameter consists of a uniform proliferation of clear cells filled up with free of intra-vesicular glycogen. Its cytological and structural features are not the same as those of the other primitive bronchopulmonary tumours having an important clear cell contingent. The histochemical and ultra-structural studies are at the origin of three hypotheses; is the benign clear cell tumor an apudoma, a smooth muscular neoplasm or an adenoma of the terminal bronchioles?
肺良性透明细胞瘤是一种罕见的肿瘤。在组织学分析之前，它常被误诊为转移瘤。本文报告1例个人观察病例，并结合文献报道的19例进行分析。该肿瘤在成年男女中发病率相等，通常无症状，多在肺部X线检查时偶然发现。肿瘤位于肺外周实质，表现为圆形、均匀、边界清晰的致密影。手术切除后预后良好。在病理研究之前，良性透明细胞瘤难以确诊。该肿瘤直径1～6 cm，由充满细胞内糖原的透明细胞均匀增生构成。其细胞和结构特征与其他富含透明细胞成分的原发性支气管肺肿瘤不同。组织化学和超微结构研究提出了三种假说：良性透明细胞瘤是APUD瘤、平滑肌瘤还是终末细支气管腺瘤？
