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[金盐诱导胆汁淤积的解剖病理学方面。两例超微结构研究报告(作者译)]

[Anatamo-pathologic aspects of gold-salt induced cholestasis. Report of two cases with ultrastructural study (author's transl)].

作者信息

Le Bodic M F, Degott C, Barrier J, Chekroun G, Gaillard F, Couprie F, Mussini-Montpellier J

出版信息

Sem Hop. 1982 Mar 4;58(9):547-53.

PMID:6278643
Abstract

The authors report two cases of gold-salt-induced cholestasis. They make a review of the thirteen cases previously related in the literature ; the cholestasis was constant, the hepatocytic necrosis was unusual and the gold-salts were difficult to visualize in the liver biopsy and more especially at the ultrastructural level. The immunological mechanism of hypersensibility is well established ; the possibility of an associated hepatotoxicity is debated.

摘要

作者报告了两例金盐诱导的胆汁淤积病例。他们回顾了文献中先前报道的13例病例;胆汁淤积是持续存在的,肝细胞坏死并不常见,并且在肝活检中,尤其是在超微结构水平上,金盐很难被观察到。超敏反应的免疫机制已得到充分证实;关于是否存在相关肝毒性的可能性仍存在争议。

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