Lebedeva G A, Deriabin P G, Loginova N V
Vopr Virusol. 1981 Nov-Dec(6):731-5.
The capacity of 3 members of the tick-borne encephalitis virus complex (Langat Tp-21, Sophyin, Elantsev) differing in their biological properties to induce chronic infection in primary cultures of suckling Syrian hamster brain cells (SHB) was studied. Three types of the infectious process were observed in these cells. Langat Tp-21 virus showed cytoproliferative activity in chronically infected SHB cell cultures; formation of cell colonies and alternation of phases of destruction and repopulation were observed with persisting Sophyin strain. The Elantsev strain in these cells produced infection with unestablished virus-cell equilibrium. The persisting viruses were shown to undergo changes in their biological properties consisting in the loss of the hemagglutinating activity and reduced pathogenicity for the susceptible animals.
研究了蜱传脑炎病毒复合体的3个成员（兰加特Tp - 21、索菲因、叶兰采夫），它们的生物学特性不同，研究其在叙利亚乳仓鼠脑细胞（SHB）原代培养物中诱导慢性感染的能力。在这些细胞中观察到三种感染过程类型。兰加特Tp - 21病毒在慢性感染的SHB细胞培养物中表现出细胞增殖活性；持续存在的索菲因毒株观察到细胞集落的形成以及破坏和再增殖阶段的交替。叶兰采夫毒株在这些细胞中产生的感染中病毒与细胞的平衡未确立。持续存在的病毒显示其生物学特性发生变化，包括血凝活性丧失和对易感动物的致病性降低。
