β-内啡肽可保护小鼠免受鼠冠状病毒MHV-JHM诱导的神经疾病侵害。
Beta-endorphin protects mice from neurological disease induced by the murine coronavirus MHV-JHM.
作者信息
Gilmore W, Moradzadeh D S
机构信息
Department of Neurology, USC School of Medicine, Los Angeles 90033.
出版信息
J Neuroimmunol. 1993 Oct;48(1):81-90. doi: 10.1016/0165-5728(93)90061-3.
The neurotropic murine coronavirus, MHV-JHM (JHMV) causes encephalitis and paralytic-demyelinating disease in susceptible strains of mice and rats, serving as a model for human demyelinating diseases such as multiple sclerosis. In this communication, we report that a single intracerebral administration of the naturally occurring neuropeptide, beta-endorphin, reduced the incidence of JHMV-induced paralytic-demyelinating disease 40-50% in C57Bl/6 mice. Protection from disease was accompanied by significantly reduced virus replication in the brain as early as 3 days post-infection and did not occur in irradiated, or immunoincompetent mice. The data suggest that beta-endorphin engages immune mechanisms of host resistance to JHMV infection to protect the mice from disease.
嗜神经性小鼠冠状病毒MHV-JHM（JHMV）可在易感品系的小鼠和大鼠中引发脑炎和麻痹性脱髓鞘疾病，是人类脱髓鞘疾病如多发性硬化症的模型。在本通讯中，我们报告单次脑内注射天然存在的神经肽β-内啡肽可使C57Bl/6小鼠中JHMV诱导的麻痹性脱髓鞘疾病发病率降低40-50%。对疾病的保护作用伴随着感染后3天大脑中病毒复制的显著减少，且在受辐照或免疫功能不全的小鼠中未出现这种情况。数据表明，β-内啡肽参与了宿主抵抗JHMV感染的免疫机制，从而保护小鼠免受疾病侵害。
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