Pattillo R A
Am J Reprod Immunol (1980). 1980;1(1):29-34. doi: 10.1111/j.1600-0897.1980.tb00007.x.
The genetic makeup of an individual may determine the capacity of the individual to combat successfully cancer and other disease states, eg abnormal pregnancies, abortions, infertility, and preeclampsia. These factors appear to be based upon the individual's immunogenetics, as histocompatibility-restricted T-cell cytotoxicity may be deficient in the observed instances of increased histocompatibility between husband and wife found in trophoblast tumor patients and in other instances of abnormal pregnancies.
个体的基因构成可能决定其成功对抗癌症和其他疾病状态的能力,例如异常妊娠、流产、不孕和先兆子痫。这些因素似乎基于个体的免疫遗传学,因为在滋养层肿瘤患者中以及在其他异常妊娠的情况下,观察到夫妻之间组织相容性增加,此时组织相容性限制的T细胞细胞毒性可能会不足。