The purpose of this paper is to describe models of ion channels in membranes which are built around a central core of ordered water. The calculated characteristics of such channels will be described and compared when possible with the measured properties of real ion channels. The approach is descriptive with reference when necessary to more detailed calculations contained in two previous papers (Edmonds, 1979, 1980). To place in perspective the problems of designing realistic model mechanisms for the translocation of ions across lipid membranes, the electrostatic self energy of a charged particle is introduced at the start. The severe limitations this energy places upon the environment that an ion must experience in traversing the lipid bilayer are briefly discussed.
Zotero 插件