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[具有两种构象状态离子通道的膜中的共振事件]

[resonant events in membranes having ion channels with two conformational states].

作者信息

Markevich N I, Sel'kov E E

出版信息

Biofizika. 1983 Mar-Apr;28(2):260-5.

PMID:6303447
Abstract

A study was carried out of a mathematical model of ion transport through biological membranes along the channels capable of conformational transitions between two states (R, T) with different conductivities. The model describes changes in time of te membrane potential and surface concentration of channels in one of the states (R). It has been shown that there may exist extinguishing oscillations with the frequency close to f0 on such a system may induce the resonance changes of the membrane potential. The resonance frequency f0 increases with an increase of the amplitude of external influence, this induces hesteresis of the membrane resonance parameters.

摘要

对离子通过生物膜沿能够在两种具有不同电导率的状态(R,T)之间进行构象转变的通道进行传输的数学模型进行了一项研究。该模型描述了膜电位和处于其中一种状态(R)的通道表面浓度随时间的变化。结果表明,在这样的系统上可能存在频率接近f0的熄灭振荡,其可能诱导膜电位的共振变化。共振频率f0随着外部影响幅度的增加而增加,这导致膜共振参数的滞后现象。

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