Ryan J R, Baker L H, Benjamin R S
Clin Orthop Relat Res. 1982 Apr(164):257-60.
Of 35 treated cases of metastatic synovial sarcoma, there was a slight male predominance (60%). The median age was 33 years, with 88% of the patients being white. The lower extremity was the most common primary site, occurring in 66% of the cases. The most common metastatic involvement was pulmonary (33 patients), with only three patients having lymph node involvement. The low incidence of lymph node involvement and the poor prognosis when positive lymph nodes are found suggest that prophylactic lymph node resection is unwarranted. The median time from evidence of metastases to death was ten months. The complete and partial response rate to chemotherapy in this series was 50%; however, duration of the response was rather short with recurrence of metastatic disease a median of seven months after response was first noted. The size of the primary lesion was greater than 5 cm in all but one of the cases. The local recurrence rate was 70% in those cases undergoing local resection and 30% in those cases in which local resection plus irradiation to the primary lesion was undertaken. No case in which radical resection of the primary tumor was undertaken had a local recurrence.
在35例接受治疗的转移性滑膜肉瘤患者中，男性略占优势（60%）。中位年龄为33岁，88%的患者为白人。下肢是最常见的原发部位，占66%的病例。最常见的转移部位是肺部（33例患者），只有3例患者有淋巴结转移。淋巴结转移发生率低，且发现阳性淋巴结时预后较差，这表明预防性淋巴结切除没有必要。从出现转移证据到死亡的中位时间为10个月。该系列中化疗的完全缓解率和部分缓解率为50%；然而，缓解持续时间较短，转移性疾病复发的中位时间为首次记录缓解后的7个月。除1例病例外，所有病例的原发灶大小均大于5 cm。接受局部切除的病例局部复发率为70%，接受局部切除加原发灶放疗的病例局部复发率为30%。接受原发肿瘤根治性切除的病例均无局部复发。
