Okada T, Hirao F, Furukawa S
Jpn J Antibiot. 1982 Jan;35(1):91-104.
Ceftizoxime was tried in children with various infections and the following results were obtained. 1) Serum levels and urinary recovery of ceftizoxime were studied in 6 patients aged from 6 to 10 years. After intravenous bolus injection of 20 mg/kg, the mean serum concentrations were 113.9 micrograms/ml, 47.6 micrograms/ml, 31.8 micrograms/ml, 18.5 micrograms/ml, 6.3 micrograms/ml and 2.1 micrograms/ml at 5 minutes, 30 minutes, 1 hour, 2 hours, 4 hours and 6 hours, respectively. The average urinary recovery rates of ceftizoxime were 55.1%, 90.9% and 98.3% at 2 hours, 4 hours and 6 hours after the administration, respectively. 2) The therapeutic efficacy was excellent in 11, good in 9 and poor in 2 patients, the efficacy rate being 91%. 3) As for the side effects, elevation of S-GOT and S-GPT, and drug fever were observed in 1 case, but disappeared soon after discontinuation of the therapy.
头孢唑肟用于患有各种感染的儿童，并取得了以下结果。1）对6名6至10岁的患者研究了头孢唑肟的血清水平和尿回收率。静脉推注20mg/kg后，5分钟、30分钟、1小时、2小时、4小时和6小时的平均血清浓度分别为113.9微克/毫升、47.6微克/毫升、31.8微克/毫升、18.5微克/毫升、6.3微克/毫升和2.1微克/毫升。给药后2小时、4小时和6小时头孢唑肟的平均尿回收率分别为55.1%、90.9%和98.3%。2）11例患者治疗效果极佳，9例良好，2例不佳，有效率为91%。3）至于副作用，1例出现谷草转氨酶和谷丙转氨酶升高以及药物热，但停药后很快消失。
