Ogawa A, Aso K, Miyachi Y, Nishikawa K, Yafuso M, Kuno K
Jpn J Antibiot. 1982 Jan;35(1):152-9.
Experimental and clinical trials were carried out with ceftizoxime in pediatric infections. Results were as follows. 1. The antibacterial activity of ceftizoxime against clinically isolated organisms was determined. Ceftizoxime was more active than cefazolin, cefotiam and cefmetazole against K. pneumoniae, E. coli and H. influenzae. 2. The serum concentrations of ceftizoxime following intravenous injection of 10 mg/kg were 16.2, 10.1, 6.2, 1.8 micrograms/ml at 30, 60, 120, 240 minutes after injection, respectively. Ceftizoxime was excreted with the rate of 97.2% in the 6-hour urine after injection. 3. Twenty-one patients comprising 5 with urinary tract infection, 16 with respiratory tract infection were received ceftizoxime at the doses ranging from 32 to 109 mg/kg divided 3 or 4 times a day. The results were excellent in 8 and good in 13 patients. The rate of satisfactory clinical response was 100%. 4. Slight and transient elevation of GPT was observed in 1 patient. Other side effects were not observed in any of these 21 patients.
用头孢唑肟对小儿感染进行了实验和临床试验。结果如下：1. 测定了头孢唑肟对临床分离菌的抗菌活性。头孢唑肟对肺炎克雷伯菌、大肠杆菌和流感嗜血杆菌的活性比头孢唑林、头孢替安和头孢美唑更强。2. 静脉注射10mg/kg后，头孢唑肟在注射后30、60、120、240分钟时的血清浓度分别为16.2、10.1、6.2、1.8μg/ml。注射后6小时内，头孢唑肟以97.2%的速率经尿液排出。3. 21例患者，包括5例尿路感染患者和16例呼吸道感染患者，接受了头孢唑肟治疗，剂量为32至109mg/kg，分3或4次给药。结果8例患者疗效优异，13例患者疗效良好。临床有效率为100%。4. 1例患者观察到谷丙转氨酶轻微短暂升高。这21例患者中均未观察到其他副作用。
