Watanabe E, Ogawa K, Ban M, Satake T
Jpn J Med. 1981 Jul;20(3):180-7. doi: 10.2169/internalmedicine1962.20.180.
To evaluate the sympathetic nervous activity in chronic hypoxic states, the plasma concentrations of norepinephrine (NE), cyclic adenosine 3', 5'-monophosphate (cyclic AMP), cyclic guanosine 3', 5'-monophosphate (cyclic GMP) and dopamine-beta-hydroxylase (DBH) enzyme activity were measured in 32 patients with pulmonary tuberculosis and 30 normal volunteers. Moreover, the peripheral arterial-venous difference of concentration of these substance, arterial blood gas levels and spirometric data were studied in these patients. The results of this study demonstrated that the plasma NE and cyclic AMP concentrations were directly related to the degree of hypoxemia and some of the spirometric parameters in these patients. It is concluded that sympathetic nervous activity was augmented in chronic hypoxic states, especially with chronic respiratory failure.
为评估慢性缺氧状态下的交感神经活动，对32例肺结核患者和30名正常志愿者测定了血浆去甲肾上腺素（NE）、环磷腺苷（环磷酸腺苷）、环鸟苷酸（环磷酸鸟苷）浓度及多巴胺-β-羟化酶（DBH）活性。此外，还研究了这些患者外周动脉-静脉这些物质浓度差、动脉血气水平和肺功能数据。本研究结果表明，这些患者血浆NE和环磷酸腺苷浓度与低氧血症程度及部分肺功能参数直接相关。得出的结论是，慢性缺氧状态下交感神经活动增强，尤其是在慢性呼吸衰竭时。
