Suen J Y, Johns M E
Laryngoscope. 1982 Mar;92(3):235-9. doi: 10.1288/00005537-198203000-00003.
Salivary gland cancers are usually treated with surgery and irradiation; however, some of the aggressive salivary gland cancers recur or metastasize and are not amendable to treatment with further surgery or irradiation. Little is known about chemotherapy for these palliative situations because of the relatively scarcity of these cancers. The data in the literature has provided little clinical information because all salivary gland cancers are usually lumped together and/or multiple different drug combination are used. In an effort to arrive at a rational basis for recommending specific drug regimens for specific histologic types of salivary gland cancers, a two-part study was undertaken to determine which chemotherapy drugs seem to be effective or ineffective. One part was a literature review, and the second part was a survey of numerous institutions' experiences, including our own. A total of 85 cases of salivary gland cancers treated with chemotherapy were felt to be evaluable for this study. The overall response rate (complete and partial) was 42%. Although disease responded whether it was local, regional, or distant disease, there was a higher response rate in local-regional disease compared to distant metastases. Salivary gland cancers are definitely sensitive to chemotherapy drugs. This study reveals which drugs seem to be effective and provides some rational basis for future chemotherapy trials for salivary gland cancers.
唾液腺癌通常采用手术和放疗进行治疗；然而，一些侵袭性唾液腺癌会复发或转移，无法通过进一步手术或放疗进行治疗。由于这类癌症相对较少，对于这些姑息治疗情况的化疗了解甚少。文献中的数据提供的临床信息很少，因为所有唾液腺癌通常被归为一类，并且/或者使用了多种不同的药物组合。为了为推荐针对特定组织学类型唾液腺癌的特定药物方案找到合理依据，开展了一项分为两部分的研究，以确定哪些化疗药物似乎有效或无效。一部分是文献综述，第二部分是对众多机构（包括我们自己的机构）经验的调查。本研究共纳入了85例接受化疗的唾液腺癌病例。总体缓解率（完全缓解和部分缓解）为42%。尽管无论是局部、区域还是远处疾病都有反应，但与远处转移相比，局部-区域疾病的缓解率更高。唾液腺癌对化疗药物肯定敏感。这项研究揭示了哪些药物似乎有效，并为未来唾液腺癌的化疗试验提供了一些合理依据。
