Lamey B
Med Trop (Mars). 1981 Nov-Dec;41(6):661-3.
Report of a case of histoplasmosis observed in Zaïre with lymphatic, pulmonary and intestinal localizations. Histoplasma duboisii was abundant in the stools, sputum and lymphatic tissue. With no amphotericine B available, treatment first started with high dosage of miconazole which had no effect. Ketoconazole have been, then, tried, giving a clinical and biological improvement, but patient still in a very bad condition, died. Ketoconazole seems to have a rapid but not lasting effect, even with increased dosages.
扎伊尔观察到的一例组织胞浆菌病报告，有淋巴、肺和肠道定位。杜波伊斯组织胞浆菌在粪便、痰液和淋巴组织中大量存在。由于没有两性霉素B，治疗首先从高剂量咪康唑开始，但没有效果。然后尝试了酮康唑，临床和生物学状况有所改善，但患者仍处于非常糟糕的状态，最终死亡。酮康唑似乎有快速但不持久的效果，即使增加剂量也是如此。
