Van de Vaart F J, Hulshoff A, Indemans A W
Pharm Weekbl Sci. 1982 Feb 19;4(1):16-20. doi: 10.1007/BF02112352.
The possibilities for the determination of active components in creams by acid-base titrations in non-aqueous solvents were investigated. Interference by cream-base components with the titration of weak organic bases and their halides with perchloric acid in acetic acid, and with the titration of weak acids with tetrabutylammonium hydroxide in N,N-dimethylformamide were studied. It appeared to be possible to determine alkaloid halides, salicylic acid, hexachlorophene and methyl salicylate without previous clean-up of the cream samples.
研究了在非水溶剂中通过酸碱滴定法测定乳膏中活性成分的可能性。研究了乳膏基质成分对在乙酸中用高氯酸滴定弱有机碱及其卤化物以及在N，N-二甲基甲酰胺中用氢氧化四丁铵滴定弱酸的干扰。结果表明，无需预先对乳膏样品进行净化处理，就有可能测定生物碱卤化物、水杨酸、六氯酚和水杨酸甲酯。
